Treatment with an artificial, nontoxic prion protein (PrP) could substantially delay or even prevent the development of prion disease, according to a new study (Claudio Soto and colleagues) in a hamster model of prion disease. Researchers found that synthetic prions — dubbed ‘anti-prions’ — competed with pathogenic PrP to protect the animals against the disease. […]
In the Golgi-ER retrograde pathway, sorting of membrane proteins occurs throughout the interaction of coat proteins with their cytoplasmic domains. A putative dilysine motif is present within the C-terminal domain (-6 to -7) of the KDEL receptor. This dilysine motif is required for interaction with coatomer (COPI is a coatomer, a protein complex that coats vesicles
Need of two lysine (K) in the signal sequence of KDEL receptors Read More »
Intracellular ratio of rNTP/ dNTP is very high. DNA polymerase: It actively discriminates against rNTPs via a “STERIC gate” formed by the Glu and Phe side chains, which excludes 2′-OH group of rNTP. But because of high concentration of rNTPs, they still get incorporated into DNA by Pol δ and ε. rNTP incorporation rate is
Discrimination of dNTPs and rNTPs by DNA polymerase and RNA polymerase Read More »
Before questioning Dark DNA existence, one should understand what is Dark DNA? We call the hidden sequence “dark DNA” as a reference to dark matter, the stuff that we think makes up about 25% of the universe but that we can’t actually detect. So the dark DNA is sequence which is present in genome; but
a. HLA = Human leukocyte antigen, typing is a method to determine how closely the tissues of one person match the tissues of another person. Human leukocyte antigens are proteins you inherit from your parents. Together, your HLA proteins, or markers, make up your HLA type. We currently know of more than 2,500 different HLA markers.HLA typing is used to match
Difference between HLA matching and DNA profiling Read More »